A family of putative transcription termination factors shared amongst metazoans and plants

被引：120

作者：

Linder, T

Park, CB

Asin-Cayuela, J

Pellegrini, M

Larsson, NG

Falkenberg, M

Samuelsson, T

Gustafsson, CM ^{[1
]}

机构：

[1] Novum, Div Metab Dis, Dept Lab Med, Karolinska Inst, SE-14186 Huddinge, Sweden

[2] Univ Gothenburg, Dept Med Biochem, SE-40530 Gothenburg, Sweden

来源：

CURRENT GENETICS | 2005年 / 48卷 / 04期

关键词：

mTERF; transcription; mitochondrion; termination;

D O I：

10.1007/s00294-005-0022-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.

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收藏

页码：265 / 269

页数：5

相关论文

共 26 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2] A kingdom-level phylogeny of eukaryotes based on combined protein data [J].

Baldauf, SL ;

Roger, AJ ;

Wenk-Siefert, I ;

Doolittle, WF .

SCIENCE, 2000, 290 (5493) :972-977

[3] ANIMALS AND FUNGI ARE EACH OTHERS CLOSEST RELATIVES - CONGRUENT EVIDENCE FROM MULTIPLE PROTEINS [J].

BALDAUF, SL ;

PALMER, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11558-11562

[4]

Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkr1065, 10.1093/nar/gkh121]

[5] Gene expression in plant mitochondria: transcriptional and post-transcriptional control [J].

Binder, S ;

Brennicke, A .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2003, 358 (1429) :181-188

[6]

DAGA A, 1993, J BIOL CHEM, V268, P8123

[7] ADDITION OF A 29-RESIDUE CARBOXYL-TERMINAL TAIL CONVERTS A SIMPLE HMG BOX-CONTAINING PROTEIN TRANSCRIPTIONAL ACTIVATOR [J].

DAIRAGHI, DJ ;

SHADEL, GS ;

CLAYTON, DA .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 249 (01) :11-28

[8] Predicting subcellular localization of proteins based on their N-terminal amino acid sequence [J].

Emanuelsson, O ;

Nielsen, H ;

Brunak, S ;

von Heijne, G .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 300 (04) :1005-1016

[9] Sea urchin mtDBP is a two-faced transcription termination factor with a biased polarity depending on the RNA polymerase [J].

Fernandez-Silva, P ;

Polosa, PL ;

Roberti, M ;

Di Ponzio, B ;

Gadaleta, MN ;

Montoya, J ;

Cantatore, P .

NUCLEIC ACIDS RESEARCH, 2001, 29 (22) :4736-4743

[10] PURIFICATION AND CHARACTERIZATION OF HUMAN MITOCHONDRIAL TRANSCRIPTION FACTOR-I [J].

FISHER, RP ;

CLAYTON, DA .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (08) :3496-3509