Role for Cysteine Protease Cathepsins in Heart Disease Focus on Biology and Mechanisms With Clinical Implication

被引：159

作者：

Cheng, Xian Wu ^{[1
,5
,6
]}

Shi, Guo-Ping ^{[2
]}

Kuzuya, Masafumi ^{[3
]}

Sasaki, Takeshi ^{[4
]}

Okumura, Kenji

Murohara, Toyoaki

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Cardiol, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Nagoya Univ, Grad Sch Med, Dept Geriatr, Nagoya, Aichi 4668550, Japan

[4] Hamamatsu Univ Sch Med, Dept Anat & Neurosci, Hamamatsu, Shizuoka 4312102, Japan

[5] Kyung Hee Univ Hosp, Dept Internal Med, Seoul, South Korea

[6] Yanbian Univ Hosp, Dept Cardiol, Yanji, Peoples R China

来源：

CIRCULATION | 2012年 / 125卷 / 12期

基金：

美国国家卫生研究院;

关键词：

cathepsins; cysteine proteases; cystatin C; extracellular matrix proteins; heart diseases; models; theoretical; ISCHEMIA-INDUCED NEOVASCULARIZATION; AORTIC-VALVE CALCIFICATION; RAT PROCATHEPSIN-B; CYSTATIN-C; CRYSTAL-STRUCTURE; REDUCES ATHEROSCLEROSIS; LYSOSOMAL CATHEPSINS; INCREASED EXPRESSION; SECRETORY VESICLES; STRUCTURAL BASIS;

D O I：

10.1161/CIRCULATIONAHA.111.066712

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

[No abstract available]

引用

收藏

页码：1551 / 1562

页数：12

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