From hindbrain segmentation to breathing after birth -: Developmental patterning in rhombomeres 3 and 4

被引:26
作者
Chatonnet, F
del Toro, ED
Thoby-Brisson, M
Champagnat, J
Fortin, G
Rijli, FM
Thaëron-Antôno, C
机构
[1] CNRS, UPR 2216, Neurobiol Genet & Integrat, Inst Neurobiol Alfred Fessad, F-91198 Gif Sur Yvette, France
[2] Univ Pablo Olavide, Lab Andaluz Biol, Div Neurociencias, Seville 41013, Spain
[3] CNRS, INSERM, ULP, Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France
关键词
D O I
10.1385/MN:28:3:277
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Respiration is a rhythmic motor behavior that appears in the fetus and acquires a vital importance at birth. It is generated within central pattern-generating neuronal networks of the hind-brain. This region of the brain is of particular interest since it is the most understood part with respect to the cellular and molecular mechanisms that underlie its development. Hox paralogs and Hox-regulating genes kreisler/mafB and Krox20 are required for the normal formation of rhombomeres in vertebrate embryos. From studies of rhombomeres r3 and r4, the authors review mechanisms whereby these developmental genes may govern the early embryonic development of para-facial neuronal networks and specify patterns of motor activities operating throughout life. A model whereby the regional identity of progenitor cells can be abnormally specified in r3 and r4 after a mutation of these genes is proposed. Novel neuronal circuits may develop from some of these misspecified progenitors while others are eliminated, eventually affecting respiration and survival after birth.
引用
收藏
页码:277 / 293
页数:17
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