Novel cytotoxic 4-phenylfuranocoumarins from Calophyllum dispar

被引:88
作者
Guilet, D
Hélesbeux, JJ
Séraphin, D
Sévenet, T
Richomme, P
Bruneton, J
机构
[1] UFR Sci Pharmaceut & Ingn Sante, SONAS, F-49100 Angers, France
[2] CENS, ICSN, F-91191 Gif Sur Yvette, France
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 05期
关键词
D O I
10.1021/np000517o
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Eight new 4-phenylfuranocoumarins (1-8) have been isolated from the stem bark and the fruits of Calophyllum dispar, together with three known coumarins. The structures of 1-8 were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these furanocoumarins exhibited significant cytotoxic activity against KB cells.
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页码:563 / 568
页数:6
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