Practical radical cyclisations leading to the construction of near-stereopure quaternary carbon stereogenic centres

被引：58

作者：

McCague, R

Pritchard, RG

Stoodley, RJ

Williamson, DS

机构：

[1] Univ Manchester, Inst Sci & Technol, Dept Chem, Manchester M60 1QD, Lancs, England

[2] Chirotech Technol Ltd, Cambridge CB4 4WE, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 24期

关键词：

D O I：

10.1039/a807930g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl auxiliary is effective in directing bromopropargyloxy additions to the olefinic bonds of vinylogous esters/carbonates; in the presence of AIBN and 1-ethylpiperidinium hypophosphite, the adducts undergo highly stereoselective reductive radical cyclisations in which quaternary carbon stereogenic centres are generated.

引用

页码：2691 / 2692

页数：2

共 12 条

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