An unprecedented arylcarbene formation in thermal reaction of non-conjugated aromatic enetetraynes and DNA strand cleavage

被引:31
作者
Ueda, I [1 ]
Sakurai, Y [1 ]
Kawano, T [1 ]
Wada, Y [1 ]
Futai, M [1 ]
机构
[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan
关键词
D O I
10.1016/S0040-4039(98)02340-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The thermal cyclization of non-conjugated aromatic enetetrayne (4) led to the final products (2 and 10) affording 5H-12-hydroxybenzo[d]fluoreno[3,2-b]pyran radical (C) and arylcarbene (D) intermediates. DNA strand cleavage was observed. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:319 / 322
页数:4
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