FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis

被引：89

作者：

Ishii, H ^{[1
]}

Vecchione, A ^{[1
]}

Murakumo, Y ^{[1
]}

Baldassarre, G ^{[1
]}

Numata, S ^{[1
]}

Trapasso, F ^{[1
]}

Alder, H ^{[1
]}

Baffa, R ^{[1
]}

Croce, CM ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 18期

关键词：

D O I：

10.1073/pnas.181222898

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The FEZ1/LZTS1 gene maps to chromosome 8p22, a region that is frequently deleted in human tumors. Alterations in FEZ1/LZTS1 expression have been observed in esophageal, breast, and prostate cancers. Here, we show that introduction of FEZ1/LZTS1 into Fez1/Lzts1-negative cancer cells results in suppression of tumorigenicity and reduced cell growth with accumulation of cells at late S-G(2)/M stage of the cell cycle. Fez1/Lzts1 protein is hyperphosphorylated by cAMP-dependent kinase during cell-cycle progression. We found that Fez1/Lzts1 is associated with microtubule components and interacts with p34(cdc2) at late S-G(2)/M stage in vivo. Present data show that FEZ1/LZTS1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth.

引用

页码：10374 / 10379

页数：6

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