The role of chromatin structure in regulating the expression of clustered genes

被引：234

作者：

Sproul, D ^{[1
]}

Gilbert, N ^{[1
]}

Bickmore, WA ^{[1
]}

机构：

[1] MRC, Human Genet Unit, Chromosomes & Gene Express Sect, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 10期

关键词：

D O I：

10.1038/nrg1688

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Much of what we know about the chromatin-based mechanisms that regulate gene expression in mammals has come from the study of what are, paradoxically, atypical genes. These are clusters of structurally and/or functionally related genes that are coordinately regulated during development, or between different cell types. Can unravelling the mechanisms of gene regulation at these gene clusters help us to understand how other genes are controlled? Moreover, can it explain why there is clustering of apparently unrelated genes in mammalian genomes?

引用

页码：775 / 781

页数：7

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