Tissue factor, angiogenesis and tumour progression

被引：82

作者：

Bluff, Joanne E. ^{[1
]}

Brown, Nicola J. ^{[1
]}

Reed, Malcolm W. R. ^{[1
]}

Staton, Carolyn A. ^{[1
]}

机构：

[1] Sch Med & Biomed Sci, Acad Unit Surg Oncol, Microbiol Res Grp, Sheffield S10 2RX, S Yorkshire, England

来源：

BREAST CANCER RESEARCH | 2008年 / 10卷 / 02期

关键词：

D O I：

10.1186/bcr1871

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tissue factor, the primary initiator of the coagulation cascade, maintains vascular integrity in response to injury. It is now recognised that, in addition to the role as a procoagulant activator, tissue factor participates in many tumour-related processes that contribute to malignant disease progression. The present review details the recent evidence supporting a role for tissue factor in tumour haemostasis, angiogenesis, metastasis and malignant cell survival. Furthermore, future research directions are discussed that may enhance our understanding of the role and regulation of this protein, which could ultimately lead to the innovative design and development of new anticancer therapies.

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页数：10

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