Nanoparticle and targeted systems for cancer therapy

被引：1571

作者：

Brannon-Peppas, L ^{[1
]}

Blanchette, JO ^{[1
]}

机构：

[1] Univ Texas, Dept Biomed Engn, Austin, TX 78712 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2004年 / 56卷 / 11期

关键词：

targeted delivery; nanoparticles; cancer therapy; angiogenesis; antibodies;

D O I：

10.1016/j.addr.2004.02.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anticancer agents or through methods of delivery. These areas include delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting. Treatment opportunities using antibody-targeted therapies are summarized. The ability to treat cancer by targeting delivery through angiogenesis is also discussed and antiangiogenic drugs in clinical trials are presented. Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1649 / 1659

页数：11

共 43 条

[31] Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes [J].

Ogris, M ;

Walker, G ;

Blessing, T ;

Kircheis, R ;

Wolschek, M ;

Wagner, E .

JOURNAL OF CONTROLLED RELEASE, 2003, 91 (1-2) :173-181

[32] Nanoparticle-mediated gene delivery to tumour neovasculature [J].

Reynolds, AR ;

Moghimi, SM ;

Hodivala-Dilke, K .

TRENDS IN MOLECULAR MEDICINE, 2003, 9 (01) :2-4

[33]

Rodolfo M, 1998, CANCER RES, V58, P5812

[34] Endothelial cells and angiogenesis [J].

Sepp, N ;

Fritsch, P ;

Luger, TA .

EXPERIMENTAL DERMATOLOGY, 1997, 6 (05) :272-273

[35] In vitro cellular accumulation of gadolinium incorporated into chitosan nanoparticles designed for neutron-capture therapy of cancer [J].

Shikata, F ;

Tokumitsu, H ;

Ichikawa, H ;

Fukumori, Y .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2002, 53 (01) :57-63

[36] Paclitaxel and its formulations [J].

Singla, AK ;

Garg, A ;

Aggarwal, D .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 235 (1-2) :179-192

[37] Exploiting the hallmarks of cancer: the future conquest of breast cancer [J].

Sledge, GW ;

Miller, KD .

EUROPEAN JOURNAL OF CANCER, 2003, 39 (12) :1668-1675

[38] SURFACE MODIFICATION OF NANOPARTICLES TO OPPOSE UPTAKE BY THE MONONUCLEAR PHAGOCYTE SYSTEM [J].

STORM, G ;

BELLIOT, SO ;

DAEMEN, T ;

LASIC, DD .

ADVANCED DRUG DELIVERY REVIEWS, 1995, 17 (01) :31-48

[39] Enhanced tumor cell selectivity of adriamycin-monoclonal antibody conjugate via a poly(ethylene glycol)-based cleavable linker [J].

Suzawa, T ;

Nagamura, S ;

Saito, H ;

Ohta, S ;

Hanai, N ;

Kanazawa, J ;

Okabe, M ;

Yamasaki, M .

JOURNAL OF CONTROLLED RELEASE, 2002, 79 (1-3) :229-242

[40] Molecular targets and cancer therapeutics: discovery, development and clinical validation [J].

Teicher, BA .

DRUG RESISTANCE UPDATES, 2000, 3 (02) :67-73

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