α2δ and the mechanism of action of gabapentin in the treatment of pain

被引：81

作者：

Maneuf, Y. P.

Luo, Z. D.

Lee, K. ^{[1
]}

机构：

[1] GlaxoSmithKline, Ctr Excellence Drug Discovery, Harlow, Essex, England

[2] Cambridge Biotechnol Ltd, Cambridge CB2 4AT, England

[3] Univ Calif Irvine, Coll Med, Dept Anesthesiol, Irvine, CA 92717 USA

[4] Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92717 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 05期

关键词：

review; gabapentin; pregabalin; neurontin; lyrica; voltage gated calcium channel; pain;

D O I：

10.1016/j.semcdb.2006.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Gabapentin is a drug that has been widely used in the treatment of chronic pain states. Despite its widespread usage, it is only recently that light has been shed on the mechanism of action of this agent. In the current review, the authors document the pharmacological, biochemical and molecular information that has led to the identification of the alpha 2 delta 1 auxilliary subunit of voltage gated calcium channels as the target for this drug's actions. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：565 / 570

页数：6

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