Chitinous materials inhibit nitric oxide production by activated RAW 264.7 macrophages

被引：45

作者：

Hwang, SM ^{[1
]}

Chen, CY ^{[1
]}

Chen, SS ^{[1
]}

Chen, JC ^{[1
]}

机构：

[1] Food Ind Res & Dev Inst, Hsinchu 30099, Taiwan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 271卷 / 01期

关键词：

D O I：

10.1006/bbrc.2000.2602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chitinous materials have been studied in wound healing and artificial skin substitutes for many years. Nitric oxide (NO) has been shown to contribute to cytotoxicity in cell proliferation during inflammation of wound healing. In this study, we examined the effect of chitin and its derivatives on NO production by activated RAW 264.7 macrophages. Chitin and chitosan showed a significantly inhibitory effect on NO production by the activated macrophages. Hexa-N-acetylchitohexaose and penta-N-acetylchitopentaose also inhibited NO production but with less potency. However, N-acetylchitotetraose, -triose, -biose, and monomer of chitin, N-acetylglucosamine and glucosamine had little effect on NO production by the activated cells. These results suggest that the promotive effect of chitinous material on wound healing be related, at least partly, to inhibit NO production by the activated macrophages. (C) 2000 Academic Press.

引用

页码：229 / 233

页数：5

共 46 条

[1] CHITIN - NEW FACETS OF RESEARCH [J].