Oxprenolol release from bioadhesive gelatin/poly(acrylic acid) microspheres

被引：20

作者：

Leucuta, SE ^{[1
]}

Ponchel, G ^{[1
]}

Duchene, D ^{[1
]}

机构：

[1] UNIV PARIS SUD,FAC PHARM,URA CNRS 1218,F-92296 CHATENAY MALABR,FRANCE

来源：

JOURNAL OF MICROENCAPSULATION | 1997年 / 14卷 / 04期

关键词：

bioadhesive; microspheres; oxprenolol; drug release; gelatin; poly(acrylic acid);

D O I：

10.3109/02652049709033835

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional and relaxational mechanisms to the anomalous release process by fitting the data to the coupled Fickian/Case II equation. The influence of glutaraldehyde cross-linking agent concentration, the poly(acrylic acid) content, the pH of the release medium and the particle size of the heads on the drug release kinetics were evaluated and discussed.

引用

页码：511 / 522

页数：12

共 19 条

[1] SOLUTE AND PENETRANT DIFFUSION IN SWELLABLE POLYMERS .9. THE MECHANISMS OF DRUG RELEASE FROM PH-SENSITIVE SWELLING-CONTROLLED SYSTEMS [J].