Genetic predispositions to acute and chronic pancreatitis

被引：55

作者：

Whitcomb, DC

机构：

[1] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15621 USA

[2] Univ Pittsburgh, Dept Cell Biol & Physiol, Pittsburgh, PA 15621 USA

[3] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15621 USA

[4] Univ Pittsburgh, Div Gastroenterol, Pittsburgh, PA 15621 USA

[5] Univ Pittsburgh, Div Hepatol & Nutr, Pittsburgh, PA 15621 USA

[6] Univ Pittsburgh, Ctr Genom Sci, Pittsburgh, PA 15621 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2000年 / 84卷 / 03期

关键词：

D O I：

10.1016/S0025-7125(05)70238-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Advances in molecular genetics have provided the powerful tools necessary to identify the key molecules and mechanisms that underly the disease process. Continued work in this area promises to reveal new insights as new disease genes are discovered. This article focuses on the insights into the cause of acute and chronic pancreatitis gained by investigation of the HP genes, the diagnosis of the known mutations, the fascinating observation of nonpenetrance, and a look at future directions.

引用

页码：531 / +

页数：18

共 91 条

[1]

AMANN ST, 2000, IN PRESS EXPRESSION

[2] Course of alcoholic chronic pancreatitis: A prospective clinicomorphological long-term study [J].

Ammann, RW ;

Heitz, PU ;

Kloppel, G .

GASTROENTEROLOGY, 1996, 111 (01) :224-231

[3]

[Anonymous], ONL MEND INH MAN

[4]

BARTNESS MA, 1998, PANCREAS, V17, P426

[5] Evidence for a common mutation in hereditary pancreatitis [J].

Bell, SM ;

Bennett, C ;

Markham, AF ;

Lench, NJ .

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 1998, 51 (02) :115-117

[6] Premature trypsin activation in hereditary pancreatitis [J].

Blackstone, M .

GASTROENTEROLOGY, 1998, 115 (03) :796-797

[7] 3-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN PANCREATIC SECRETORY TRYPSIN-INHIBITOR (KAZAL TYPE) AND TRYPSINOGEN AT 1-8 A RESOLUTION - STRUCTURE SOLUTION, CRYSTALLOGRAPHIC REFINEMENT AND PRELIMINARY STRUCTURAL INTERPRETATION [J].

BOLOGNESI, M ;

GATTI, G ;

MENEGATTI, E ;

GUARNERI, M ;

MARQUART, M ;

PAPAMOKOS, E ;

HUBER, R .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 162 (04) :839-868

[8] Differentiation of bacterial 16S rRNA genes and intergenic regions and Mycobacterium tuberculosis katG genes by structure-specific endonuclease cleavage [J].

Brow, MAD ;

Oldenburg, MC ;

Lyamichev, V ;

Heisler, LM ;

Lyamicheva, N ;

Hall, JG ;

Eagan, NJ ;

Olive, DM ;

Smith, LM ;

Fors, L ;

Dahlberg, JE .

JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (12) :3129-3137

[9] Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography [J].

Cavallini, G ;

Tittobello, A ;

Frulloni, L ;

Masci, E ;

Mariani, A ;

DiFrancesco, V ;

Angelini, GP ;

Casarini, MB ;

Bedogni, G ;

Conigliaro, R ;

Bonardi, L ;

Khajekini, MTA ;

Cipolletta, L ;

Bianco, MA ;

Costamagna, G ;

Perri, V ;

Dobrilla, G ;

DePretis, G ;

Familiari, L ;

Giacobbe, G ;

Fratton, A ;

Carone, N ;

Loriga, P ;

Muscas, A ;

Mazzeo, F ;

Gaeta, L ;

Miglioli, M ;

Pezzilli, R ;

Morelli, A ;

Santucci, L ;

Naccarato, R ;

DelFavero, G ;

Orlandi, F ;

Macarri, GP ;

Russo, A ;

Virgilio, C ;

Uomo, G ;

Manes, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (13) :919-923

[10] Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis [J].

Cohn, JA ;

Friedman, KJ ;

Noone, PG ;

Knowles, MR ;

Silverman, LM ;

Jowell, PS .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (10) :653-658

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