Synthetic studies on pentacyclic aromatic alkaloids, kuanoniamine A, 11-hydroxyascididemin, and neocalliactine acetate

被引：27

作者：

Kitahara, Y ^{[1
]}

Nakahara, S ^{[1
]}

Yonezawa, T ^{[1
]}

Nagatsu, M ^{[1
]}

Shibano, Y ^{[1
]}

Kubo, A ^{[1
]}

机构：

[1] MEIJI COLL PHARM,SETAGAYA KU,TOKYO 154,JAPAN

来源：

TETRAHEDRON | 1997年 / 53卷 / 50期

关键词：

D O I：

10.1016/S0040-4020(97)10153-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A pentacyclic aromatic alkaloid, kuanoniamine A (6) was synthesized in three steps from 6-methoxybenzothiazole-4,7-dione (8) and 2-aminoacetophenone (9). 11-Hydroxyascididemin (4) was prepared from 5,8-quinolinedione (13, 14) or 1,4-acridinedione (20). The structure of neocalliactine acetate, a derivative of calliactine, was determined to be 5 by total synthesis from 6-methoxy-5,8-quinolinedione (28) and 2-amino-5-methoxyacetophenone (29). (C) 1997 Elsevier Science Ltd.

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收藏

页码：17029 / 17038

页数：10

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