Pro- and anti-fibrotic effects of TGF-β in scleroderma

被引：25

作者：

Sgonc, R. ^{[1
]}

Wick, G. ^{[1
]}

机构：

[1] Med Univ Innsbruck, Div Expt Pathophysiol & Immunol, Lab Autoimmun, Bioctr, A-6020 Innsbruck, Austria

来源：

RHEUMATOLOGY | 2008年 / 47卷

基金：

奥地利科学基金会;

关键词：

Systemic sclerosis; Transforming growth factor-1; Transforming growth factor-2; Transforming growth factor-3; Fibrosis; The University of California at Davis 200 chicken;

D O I：

10.1093/rheumatology/ken275

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-1) and anti-fibrotic (TGF-2 and -3) TGF- isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition.

引用

页码：V5 / V7

页数：3

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