TGF-β promotes the establishment of renal cell carcinoma bone metastasis

被引：52

作者：

Kominsky, Scott L. ^{[1
]}

Doucet, Michele ^{[1
]}

Brady, Kelly ^{[1
]}

Weber, Kristy L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21218 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 01期

关键词：

renal cell carcinoma; bone; metastasis; TGF-beta; 1; osteolysis;

D O I：

10.1359/JBMR.061005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bone metastases develop in similar to 30% of patients with RCC, and the mechanisms responsible for this phenomenon are unknown. We found that TGF-beta 1 stimulation of RCC bone metastasis cells promotes tumor growth and bone destruction possibly by stimulating paracrine interactions between tumor cells and the bone.

引用

页码：37 / 44

页数：8

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