Effect of Propofol on the Expression of MMP-9 and Its Relevant Inflammatory Factors in Brain of Rat with Intracerebral Hemorrhage

被引：12

作者：

Han, Dongji ^{[1
]}

Li, Shiyong ^{[1
]}

Xiong, Qiuju ^{[2
]}

Zhou, Ling ^{[2
]}

Luo, Ailin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Anesthesiol & Pain Med, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Wuhan Pu Ai Hosp, Dept Pain Med, Tongji Med Coll, Wuhan 430033, Hubei, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 72卷 / 03期

关键词：

Propofol; Intracerebral hemorrhage; MMP-9; Inflammatory factors;

D O I：

10.1007/s12013-015-0516-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Intracerebral hemorrhage (ICH) is bleeding in brain caused by the rupture of brain blood vessel, which may lead to patient unconsciousness or death. In this study, we measured the expression of matrix metalloproteinase-9 (MMP-9) and its relevant inflammatory factors in the brain of rat with ICH. The effect of propofol on the expression of MMP-9 and inflammatory factors was investigated. We found the water content in the brain of ICH rats was significantly higher when compared with normal brain. Expression of MMP-9 and inflammatory factors IL-1 beta and TNF-alpha were up-regulated in ICH rats. Medium or high concentration of propofol can alleviate ICH in rats by inhibition of the inflammatory factor release and up-regulation of MMP-9 in brain. Our study suggests the inflammatory response after reduction of ICH through promotion of MMP-9 expression and neurite regeneration.

引用

页码：675 / 679

页数：5

共 14 条

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