Stretching lattice models of protein folding

被引：59

作者：

Socci, ND

Onuchic, JN

Wolynes, PG

机构：

[1] Rockefeller Univ, Ctr Studies Phys & Biol, New York, NY 10021 USA

[2] Lucent Technol, Bell Labs, Murray Hill, NJ 07974 USA

[3] Univ Calif San Diego, Dept Phys 0319, La Jolla, CA 92093 USA

[4] Univ Illinois, Sch Chem Sci, Urbana, IL 61801 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 05期

关键词：

D O I：

10.1073/pnas.96.5.2031

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new class of experiments that probe folding of individual protein domains uses mechanical stretching to cause the transition. We show how stretching forces can be incorporated in lattice models of folding. For fast folding proteins, the analysis suggests a complex relation between the force dependence and the reaction coordinate for folding.

引用

收藏

页码：2031 / 2035

页数：5

相关论文

共 17 条

[1] Rate of protein folding near the point of thermodynamic equilibrium between the coil and the most stable chain fold [J].

Finkelstein, AV ;

Badretdinov, AY .

FOLDING & DESIGN, 1997, 2 (02) :115-121

[2]

Flory PJ, 1989, STAT MECH CHAIN MOL

[3] Diffusion-limited contact formation in unfolded cytochrome c: Estimating the maximum rate of protein folding [J].

Hagen, SJ ;

Hofrichter, J ;

Szabo, A ;

Eaton, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11615-11617

[4] Folding-unfolding transitions in single titin molecules characterized with laser tweezers [J].

Kellermayer, MSZ ;

Smith, SB ;

Granzier, HL ;

Bustamante, C .

SCIENCE, 1997, 276 (5315) :1112-1116

[5] PROTEIN FOLDING FUNNELS - A KINETIC APPROACH TO THE SEQUENCE STRUCTURE RELATIONSHIP [J].

LEOPOLD, PE ;

MONTAL, M ;

ONUCHIC, JN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8721-8725

[6] Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation [J].

Lu, H ;

Isralewitz, B ;

Krammer, A ;

Vogel, V ;

Schulten, K .

BIOPHYSICAL JOURNAL, 1998, 75 (02) :662-671

[7] TOWARD AN OUTLINE OF THE TOPOGRAPHY OF A REALISTIC PROTEIN-FOLDING FUNNEL [J].

ONUCHIC, JN ;

WOLYNES, PG ;

LUTHEYSCHULTEN, Z ;

SOCCI, ND .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3626-3630

[8] Protein folding funnels: The nature of the transition state ensemble [J].

Onuchic, JN ;

Socci, ND ;

LutheySchulten, Z ;

Wolynes, PG .

FOLDING & DESIGN, 1996, 1 (06) :441-450

[9] Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module [J].

Plaxco, KW ;

Spitzfaden, C ;

Campbell, ID ;

Dobson, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) :10703-10706

[10] Reversible unfolding of individual titin immunoglobulin domains by AFM [J].

Rief, M ;

Gautel, M ;

Oesterhelt, F ;

Fernandez, JM ;

Gaub, HE .

SCIENCE, 1997, 276 (5315) :1109-1112