Paradoxical Increase in Arterial Compliance in Obese Pubertal Children

被引：22

作者：

Chalmers, Laura J. ^{[1
,2
]}

Copeland, Kenneth C. ^{[1
,2
]}

Hester, Casey N. ^{[2
]}

Fields, David A. ^{[1
,2
]}

Gardner, Andrew W. ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Coll Med, Dept Pediat, Harold Hamm Oklahoma Diabet Ctr, Tulsa, OK 74135 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Sect Diabet Endocrinol,CMRI Diabet & Metab Res Pr, Tulsa, OK 74135 USA

来源：

ANGIOLOGY | 2011年 / 62卷 / 07期

基金：

美国国家卫生研究院;

关键词：

cardiovascular risk; vascular function; body composition; physical activity; obesity; CARDIOVASCULAR RISK-FACTORS; INTIMA-MEDIA THICKNESS; PULSE-WAVE VELOCITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; YOUNG-ADULTS; US CHILDREN; STIFFNESS; ADOLESCENTS;

D O I：

10.1177/0003319711399117

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We determined whether arterial compliance measured by pulse wave analysis is impaired in obese pubertal children compared to normal weight controls, and assessed whether arterial compliance is associated with ambulatory activity. Body fat percentage was significantly different between the normal (n = 33) and obese (n = 34) participants (P < .001). Large (P = .012) and small (P < .001) arterial compliance were lower in the normal-weight group. After adjusting for height, systolic and diastolic blood pressure, race, sex, and Tanner stage, large arterial compliance was no longer different between groups (P = .066), whereas small arterial compliance remained higher in the obese group (P < .001). Obese pubertal children have paradoxically increased small arterial compliance compared to that of normal weight children, even after adjusting for height, blood pressure, race, sex, and Tanner stage. Thus, obesity in adolescence is not associated with impairments in small arterial compliance.

引用

页码：565 / 570

页数：6

共 42 条

[1] The influence of obesity on arterial compliance in adult men and women [J].