Effects of estrogen replacement therapy on human brain aging:: An in vivo 1H MRS study

被引：49

作者：

Robertson, DMW

van Amelsvoort, T

Daly, E

Simmons, A

Whitehead, M

Morris, RG

Murphy, KC

Murphy, DGM

机构：

[1] Maudsley Hosp & Inst Psychiat, Dept Neuroimaging, London SE5 8AZ, England

[2] Harvard Univ, Sch Med, Dept Obstet & Gynaecol, Cambridge, MA 02138 USA

[3] Kings Coll London Hosp, Sch Med, Dept Obstet & Gynaecol, London, England

[4] Inst Psychiat, Neuropsychol Unit, London, England

[5] Inst Psychiat, Dept Neurol, London SE5 8AF, England

[6] Inst Psychiat, Dept Med Psychol, London, England

来源：

NEUROLOGY | 2001年 / 57卷 / 11期

关键词：

D O I：

10.1212/WNL.57.11.2114

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Estrogen replacement therapy (ERT) may preserve cognitive function in postmenopausal women, but the mechanism is unknown. Thus, the authors studied aging of parietal lobe and hippocampus using proton MR spectroscopy. ERT naive postmenopausal women had a significant increase in choline-containing compounds (Cho) compared to long-term ERT users and young women. Cho reflects increased neuronal/glial membrane turnover. Thus, ERT's "neuroprotective" effect may include modulating the effects of age on neural integrity in brain regions involved in cognitive function.

引用

页码：2114 / 2117

页数：4

共 11 条

[1] In vivo H-1 MRS choline: Correlation with in vitro chemistry histology [J].