Potential of cationic porphyrins for photodynamic treatment of cutaneous Leishmaniasis

被引：42

作者：

Bristowa, Carrie-Anne ^{[1
,2
]}

Hudson, Robert ^{[1
,2
]}

Paget, Timothy A. ^{[3
,4
]}

Boyle, Ross W. ^{[1
,2
]}

机构：

[1] Univ Hull, Dept Chem, Photobiol & Photomed Grp, Kingston Upon Hull HU6 7RX, Yorks, England

[2] Univ Hull, Clin Biosci Inst, Kingston Upon Hull HU6 7RX, Yorks, England

[3] Univ Kent, Medway Sch Pharm, Canterbury ME4 4TB, Kent, England

[4] Univ Greenwich Medway, Medway Sch Pharm, Chatham ME4 4TB, Kent, England

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2006年 / 3卷 / 03期

关键词：

Leishmaniasis; Photodynamic therapy; Porphyrins;

D O I：

10.1016/j.pdpdt.2006.04.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Four tetracationic porphyrins have been investigated for their ability to photo-inactivate Leishmania major promastigotes. Parallel photocytotoxicity assays against keratinocytes and macrophages show significant differences in activity between the microorganism and mammalian cells. Results suggest that it may be possible to photodynamically inactivate macrophages infected with Leishmania and the promastigote form of the microorganism, while minimising damage to surrounding tissue. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：162 / 167

页数：6

共 19 条

[1]

Leishmaniasis - Public health aspects and control [J].