Ras regulation and function in lymphocytes

被引：140

作者：

Genot, E

Cantrell, DA

机构：

[1] Imperial Canc Res Fund, Lymphocyte Activat Lab, London WC2A 3PX, England

[2] Univ Bordeaux 1, Growth Factors & Differentiat Lab, F-33405 Talence, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00089-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The GTPase, Ras, is rapidly activated in antigen receptor stimulated T cells, B cells and mast cells. Ras can bind to diverse effector molecules when activated and thereby switch on multiple downstream effector pathways. In lymphocytes Ras plays an important role in the signalling pathways that activate transcription factors involved in cytokine gene induction. Ras is also a key component of the complex regulatory networks that control T and B cell development.

引用

收藏

页码：289 / 294

页数：6

相关论文

共 48 条

[1] SELECTIVE REQUIREMENT FOR MAP KINASE ACTIVATION IN THYMOCYTE DIFFERENTIATION [J].

ALBEROLAILA, J ;

FORBUSH, KA ;

SEGER, R ;

KREBS, EG ;

PERLMUTTER, RM .

NATURE, 1995, 373 (6515) :620-623

[2] All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral [J].

Bos, JL .

EMBO JOURNAL, 1998, 17 (23) :6776-6782

[3] Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1 [J].

Boussiotis, VA ;

Freeman, GJ ;

Berezovskaya, A ;

Barber, DL ;

Nadler, LM .

SCIENCE, 1997, 278 (5335) :124-128

[4] EPIDERMAL GROWTH-FACTOR REGULATES P21(RAS) THROUGH THE FORMATION OF A COMPLEX OF RECEPTOR, GRB2 ADAPTER PROTEIN, AND SOS NUCLEOTIDE EXCHANGE FACTOR [J].

BUDAY, L ;

DOWNWARD, J .

CELL, 1993, 73 (03) :611-620

[5] The real LAT steps forward [J].

Cantrell, D .

TRENDS IN CELL BIOLOGY, 1998, 8 (05) :180-182

[6] p62(dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells [J].

Carpino, N ;

Wisniewski, D ;

Strife, A ;

Marshak, D ;

Kobayashi, R ;

Stillman, B ;

Clarkson, B .

CELL, 1997, 88 (02) :197-204

[7] Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation [J].

Cheng, AM ;

Saxton, TM ;

Sakai, R ;

Kulkarni, S ;

Mbamalu, G ;

Vogel, W ;

Tortorice, CG ;

Cardiff, RD ;

Cross, JC ;

Muller, WJ ;

Pawson, T .

CELL, 1998, 95 (06) :793-803

[8] Integration of T cell receptor-dependent signaling pathways by adapter proteins [J].

Clements, JL ;

Boerth, NJ ;

Lee, JR ;

Koretzky, GA .

ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :89-108

[9] STIMULATION OF P21RAS UPON T-CELL ACTIVATION [J].

DOWNWARD, J ;

GRAVES, JD ;

WARNE, PH ;

RAYTER, S ;

CANTRELL, DA .

NATURE, 1990, 346 (6286) :719-723

[10] LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway [J].

Finco, TS ;

Kadlecek, T ;

Zhang, WG ;

Samelson, LE ;

Weiss, A .

IMMUNITY, 1998, 9 (05) :617-626

← 1 2 3 4 5 →