Improvement of nifedipine dissolution characteristics using supercritical CO2

被引：70

作者：

SencarBozic, P

Srcic, S

Knez, Z

Kerc, J

机构：

[1] UNIV MARIBOR,FAC CHEM & CHEM ENGN,SLO-2000 MARIBOR,SLOVENIA

[2] UNIV LJUBLJANA,FAC PHARM,SLO-1000 LJUBLJANA,SLOVENIA

[3] LEK PHARMACEUT & CHEM CO,DIV RES & DEV,LJUBLJANA 1526,SLOVENIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1997年 / 148卷 / 02期

关键词：

supercritical fluids; CO2; high pressure; micronization; nifedipine; PEG; 4000;

D O I：

10.1016/S0378-5173(96)04838-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An application of supercritical fluids (SCFs) for processing of pharmaceuticals is presented. PGSS (Particles from Gas Saturated Solutions), a novel method for high pressure material processing, has been used to improve technological characteristics of the poorly water soluble calcium antagonist nifedipine. Nifedipine was micronized with PGSS and the influence of pie-expansion conditions on the particle size was studied. With PGSS, coprecipitates of nifedipine and PEG 4000 were prepared and evaluated. The solid dispersions had enhanced dissolution rates. The PGSS process shows some advantages over classical methods for solid dispersion preparation. (C) 1997 Elsevier Science B.V.

引用

页码：123 / 130

页数：8

共 14 条

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ALLESI P, 1995, ATT 3 C FLUID SUP LO, P213

[2]

BENEDETTI L, 1995, ATT 3 C FLUID SUP LO, P221

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