Alloimmune neonatal neutropenia linked to anti-HNA-4a

被引：33

作者：

Fung, YL

Pitcher, LA

Willett, JE

Reed, C

Mison, L

Bux, J

Eiber, G

Minchinton, RM

机构：

[1] Australian Red Cross Blood Serv Queensland, Platelet & Granulocyte Immunobiol Lab, Brisbane, Qld 4000, Australia

[2] Starship Childrens Hosp, Dept Haematol Oncol, Auckland, New Zealand

[3] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[4] Univ Giessen, Inst Clin Immunol & Transfus Med, D-6300 Giessen, Germany

[5] Amer Red Cross, N Cent Blood Serv, Clin Lab Serv, Minneapolis, MN USA

来源：

TRANSFUSION MEDICINE | 2003年 / 13卷 / 01期

关键词：

alloimmune neonatal neutropenia; DNA sequencing; HNA-4a;

D O I：

10.1046/j.1365-3148.2003.00413.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This is a novel case report of alloimmune neonatal neutropenia (ANN) linked to the neutrophil antibody anti-HNA-4a (MART). Since its discovery, the HNA-4a antigen has never been associated with any clinical neutropenia. A first-born neonate with respiratory distress was found to be severely neutropenic, because of ANN. The broad reactivity of the antibody together with its capture by CD11b and CD18 in monoclonal antibody immobilization of granulocyte antigen test suggested HNA-4a specificity. DNA sequencing confirmed that the father is HNA-4a-positive and that the mother is HNA-4a-negative, supporting the diagnosis of ANN linked to MART.

引用

页码：49 / 52

页数：4

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