Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin

被引：36

作者：

Hogan, RE

Bertrand, ME

Deaton, RL

Sommerville, KW

机构：

[1] St Louis Univ, Dept Neurol, St Louis, MO 63110 USA

[2] Abbott Labs, Div Pharmaceut Prod, Abbott Pk, IL 60064 USA

来源：

EPILEPSY RESEARCH | 2000年 / 41卷 / 01期

关键词：

epilepsy; total body weight; tiagabine; carbamazepine; antiepileptic drugs;

D O I：

10.1016/S0920-1211(00)00125-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT). TGB add-on therapy showed no significant weight changes when added to either PHT or CBZ. CBZ add-on therapy showed a significant percentage weight gain of a mean body increase of 1.5% (P = 0.002). Adjunctive TGB therapy had no significant effect on total body weight, while adjunctive CBZ therapy was associated with weight gain. (C) 2000 Elsevier Science B.V. Ali rights reserved.

引用

页码：23 / 28

页数：6

共 15 条

[1] Gabapentin add-on therapy with adaptable dosages in 610 patients with partial epilepsy: an open, observational study [J].