Polarographic determination of propranolol in pharmaceutical formulation

被引：35

作者：

El-Ries, MA

Abou-Sekkina, MM

Wassel, AA

机构：

[1] Natl Org Drug Control & Res, Cairo, Egypt

[2] Tanta Univ, Fac Sci, Dept Chem, Tanta, Egypt

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 30卷 / 03期

关键词：

propranolol; drug analysis; polarography; nitrated propranolol;

D O I：

10.1016/S0731-7085(02)00087-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Propranolol was reacted with nitric acid to give nitropropranolol and was then measured in Britton-Robinson solutions in the pH range 2.0-12.0 by differential-pulse polarography. Nitropropranolol gave rise to a well-resolved differential-pulse polarographic peak at pH 2.0. A linear calibration graph in the range 5.0 x 10(-7)-5.0 x 10(-5) M and a detection limit of 5 nM was obtained. The relative standard deviation was 1.95% (n = 10) at 5 x 10(-6) M. The effect of common exceipient on the peak height was evaluated. The method was applied for the determination of the drug in the tablet dosage form. (C) 2002 Published by Elsevier Science B.V.

引用

页码：837 / 842

页数：6

共 21 条

[1] THE DIRECT DETERMINATION OF PARACETAMOL IN BIOLOGICAL-FLUIDS BY AC POLAROGRAPHY [J].