Methacholine challenge testing - Safety of low starting FEV1

被引：25

作者：

Martin, RJ ^{[1
]}

Wanger, JS ^{[1
]}

Irvin, CG ^{[1
]}

Bartelson, BB ^{[1
]}

Cherniack, RM ^{[1
]}

Drazen, JM ^{[1
]}

Israel, E ^{[1
]}

Martin, RJ ^{[1
]}

Szefler, SJ ^{[1
]}

Chinchilli, VM ^{[1
]}

Mauger, EA ^{[1
]}

Lemanske, RF ^{[1
]}

Sorkness, C ^{[1
]}

Ford, JG ^{[1
]}

McLean, D ^{[1
]}

Nochman, S ^{[1
]}

Fish, JE ^{[1
]}

Peters, SP ^{[1
]}

Boushey, HA ^{[1
]}

Lazarus, SC ^{[1
]}

Fahy, J ^{[1
]}

Cherniack, RR ^{[1
]}

Hurd, SS ^{[1
]}

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED,DENVER,CO 80206

来源：

CHEST | 1997年 / 112卷 / 01期

关键词：

asthma; methacholine challenge; safety; starting FEV1;

D O I：

10.1378/chest.112.1.53

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: The lower limit for the baseline value to initiate methacholine bronchial hyperresponsiveness testing has not been well established. Recommendations have varied from > 1 L to above 80% of predicted. The objective was to determine if an FEV1 < 60% predicted was acceptable. Design: Retrospective analysis of challenges in 88 patients with a baseline FEV1 of <60% predicted (mean=45.8%; range, 22 to 59%. Setting: Academic institutions. Results: There were only four individuals whose FEV1 did not return to >90% of baseline following one poststudy beta(2)-agonist treatment. All four responded to a second treatment. There were no adverse sequelae following challenge in any individual. Neither age (up to 79 years) nor gender influenced outcome. Conclusions: In chronic moderate to severe asthma, it appears that bronchial hyperresponsiveness testing can be safely performed even in those patients with a low baseline FEV1.

引用

页码：53 / 56

页数：4

共 12 条

[1] BRONCHIAL HYPERREACTIVITY [J].

BENSON, MK .

BRITISH JOURNAL OF DISEASES OF THE CHEST, 1975, 69 (OCT) :227-239

[2]

BHAGAT RG, 1984, AM REV RESPIR DIS, V129, P221

[3]

CROPP GJA, 1980, ATS NEWS SPR, P11

[4]

EISER NM, 1983, B EUR PHYSIOPATH RES, V19, P495

[5]

GREENSPON LW, 1986, AM REV RESPIR DIS, V133, P735

[6] INHALATION PROVOCATION TESTS [J].

HARGREAVE, FE ;

DOLOVICH, J ;

BOULET, LP .

SEMINARS IN RESPIRATORY MEDICINE, 1983, 4 (03) :224-236

[7] FACTORS RELATED TO THE NOCTURNAL WORSENING OF ASTHMA [J].

MARTIN, RJ ;

CICUTTO, LC ;

BALLARD, RD .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (01) :33-38

[8] DIFFERENCES IN RESPONSIVENESS TO HYPERVENTILATION AND METHACHOLINE IN ASTHMA AND CHRONIC-BRONCHITIS [J].

RAMSDALE, EH ;

ROBERTS, RS ;

MORRIS, MM ;

HARGREAVE, FE .

THORAX, 1985, 40 (06) :422-426

[9]

RAMSDELL JW, 1982, AM REV RESPIR DIS, V126, P829

[10] A SURVEY OF THE CURRENT USE AND METHODS OF ANALYSIS OF BRONCHOPROVOCATIONAL CHALLENGES [J].

SCOTT, GC ;

BRAUN, SR .

CHEST, 1991, 100 (02) :322-328

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