Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in HIV-tuberculosis patients

被引：43

作者：

Kabeer, Basirudeen S. A. ^{[1
]}

Sikhamani, Rajasekaran ^{[2
]}

Raja, Alamelu ^{[1
]}

机构：

[1] Tambaram Sanat, Dept Immunol, TB Res Ctr ICMR, Madras, Tamil Nadu, India

[2] Govt Hosp Thorac Med, Tambaram Sanat, Madras, Tamil Nadu, India

来源：

AIDS | 2010年 / 24卷 / 02期

基金：

美国国家卫生研究院;

关键词：

LATENT TUBERCULOSIS; RELEASE ASSAY; WHOLE-BLOOD; DIAGNOSIS; IP-10; MACROPHAGES; SENSITIVITY; EXPRESSION; INFECTION;

D O I：

10.1097/QAD.0b013e328334895e

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interferon gamma (IFN gamma)-based in-vitro assays have suboptimal sensitivity, especially in immuno-compromised individuals, which emphasizes the need for alternative markers for tuberculosis (TB) diagnosis. We compared TB antigens-specific IFN gamma and IFN gamma-inducible protein-10 levels in culture of whole blood samples from HIV-TB patients. We report that IFN gamma-inducible protein-10 detects a greater number of HIV-TB cases than IFN gamma and suggest that IFN gamma-inducible protein-10 may be a better alternative marker for latent TB infection diagnosis among immunocompromised individuals.

引用

页码：323 / 325

页数：3

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