"Intraventricular" Hemorrhage and Cystic Periventricular Leukomalacia in Preterm Infants: How Are They Related?

被引：26

作者：

Kusters, Cynthia D. J. ^{[1
,2
]}

Chen, Minghua L. ^{[2
]}

Follett, Pamela L.

Dammann, Olaf ^{[2
,3
,4
]}

机构：

[1] Radboud Univ Nijmegen, Univ Med Ctr St Radboud, Dept Epidemiol & Biostat, NL-6500 HB Nijmegen, Netherlands

[2] Tufts Med Ctr, Floating Hosp Children, Div Newborn Med, Boston, MA USA

[3] Hannover Med Sch, Perinatal Neuroepidemiol Unit, D-3000 Hannover, Germany

[4] Childrens Hosp Boston, Neuroepidemiol Unit, Boston, MA USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2009年 / 24卷 / 09期

关键词：

preterm; intraventricular hemorrhage; cystic periventricular leukomalacia; risk pattern; association; BIRTH-WEIGHT INFANTS; CRANIAL ULTRASOUND; CEREBRAL-PALSY; BRAIN-DAMAGE; OUTCOMES; PREMATURITY; RISK; ABNORMALITIES; PATHOGENESIS; INJURY;

D O I：

10.1177/0883073809338064

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Intraventricular hemorrhage and cystic periventricular leukomalacia are often co-occurring characteristics of brain damage in preterm infants. Using data from 1016 infants born before 30 completed weeks' gestational age, we sought to clarify the relationship between severe intraventricular hemorrhage and cystic periventricular leukomalacia, with special emphasis on common antecedents and potential confounding. After comparing risk factors for intraventricular hemorrhage grades I through 4 and cystic periventricular leukomalacia, it appears the risk patterns for intraventricular hemorrhage grade 3, intraventricular hemorrhage grade 4, and cystic periventricular leukomalacia differ. The association between intraventricular hemorrhage grade 3 and cystic periventricular leukomalacia differs appreciably from the association between intraventricular hemorrhage grade 4 and cystic periventricular leukomalacia, supporting the notion that intraventricular hemorrhage grade 3 and intraventricular hemorrhage grade 4 are different entities. The presence of intraventricular hemorrhage grade 3 and intraventricular hemorrhage grade 4 increases the risk of cystic periventricular leukomalacia, even after adjusting for potential confounders. This raises the possibility that intraventricular hemorrhage grade 3 and intraventricular hemorrhage grade 4 cause cystic periventricular leukomalacia.

引用

页码：1158 / 1170

页数：13

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