Zinc in cancer prevention

被引：145

作者：

Prasad, AS

Kucuk, O

机构：

[1] Wayne State Univ, Dept Med, Div Hematol Oncol, Sch Med, Detroit, MI 48202 USA

[2] Wayne State Univ, Dept Med & Mol Genet, Barbara Ann Karmanos Canc Inst, Sch Med, Detroit, MI 48202 USA

来源：

CANCER AND METASTASIS REVIEWS | 2002年 / 21卷 / 3-4期

关键词：

zinc; cancer prevention; immune function; nutrition; head and neck cancer;

D O I：

10.1023/A:1021215111729

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiologic studies suggest that zinc deficiency may be associated with increased risk of cancer. However, few studies have been conducted with zinc supplementation in animals and humans. Most previous intervention studies have used zinc in combination with several other micronutrients, which make them difficult to interpret. Zinc supplementation is associated with decreased oxidative stress and improved immune function, which may be among the possible mechanisms for its cancer preventive activity. Preclinical and clinical studies need to investigate modulation of genetic and epigenetic pathways of carcinogenesis by zinc.

引用

页码：291 / 295

页数：5

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