Stereoselective synthesis of α-alkylidene- and substituted alkylidene-γ-lactones

被引：20

作者：

Castulík, J ^{[1
]}

Mazal, C ^{[1
]}

机构：

[1] Masaryk Univ, Fac Sci, Dept Organ Chem, CS-61137 Brno, Czech Republic

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 15期

关键词：

methylene lactones; coupling reactions; palladium; zinc compounds;

D O I：

10.1016/S0040-4039(00)00252-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cross-coupling reactions of (E)- and (Z)-tosylates of alpha-hydroxymethylene-gamma-butyrolactone with aryl, heteroaryl, alkyl, and alkynylzinc chlorides under Pd(PPh3)(4) catalysis were found to be a suitable synthetic method for stereoselective preparation of alpha-alkylidene- and substituted alkylidene-gamma-lactones. The reactions, conducted under mild conditions, proceed with high stereoselectivity and moderate yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2741 / 2744

页数：4

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