Unmasking the tonic-aversive state in neuropathic pain

被引：431

作者：

King, Tamara ^{[1
]}

Vera-Portocarrero, Louis ^{[1
]}

Gutierrez, Tannia ^{[1
]}

Vanderah, Todd W. ^{[1
]}

Dussor, Gregory ^{[1
]}

Lai, Josephine ^{[1
]}

Fields, Howard L. ^{[2
]}

Porreca, Frank ^{[1
]}

机构：

[1] Univ Arizona, Dept Pharmacol, Tucson, AZ 85721 USA

[2] Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, Emeryville, CA USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 11期

关键词：

CLINICAL-TRIALS; MECHANISMS;

D O I：

10.1038/nn.2407

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tonic pain has been difficult to demonstrate in animals. Because relief of pain is rewarding, analgesic agents that are not rewarding in the absence of pain should become rewarding only when there is ongoing pain. We used conditioned place preference to concomitantly determine the presence of tonic pain in rats and the efficacy of agents that relieve it. This provides a new approach for investigating tonic pain in animals and for evaluating the analgesic effects of drugs.

引用

收藏

页码：1364 / 1366

页数：3

相关论文

共 15 条

[1] Neuropathic pain symptoms relative to overall pain rating [J].

Backonja, MM ;

Stacey, B .

JOURNAL OF PAIN, 2004, 5 (09) :491-497

[2]

Boulton AJ., 2005, Clin Diabetes, V23, P9, DOI DOI 10.2337/DIACLIN.23.1.9

[3] Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain [J].

Burgess, SE ;

Gardell, LR ;

Ossipov, MH ;

Malan, TP ;

Vanderah, TW ;

Lai, J ;

Porreca, F .

JOURNAL OF NEUROSCIENCE, 2002, 22 (12) :5129-5136

[4] Mechanisms of neuropathic pain [J].

Campbell, James N. ;

Meyer, Richard A. .

NEURON, 2006, 52 (01) :77-92

[5] Spared nerve injury: an animal model of persistent peripheral neuropathic pain [J].

Decosterd, I ;

Woolf, CJ .

PAIN, 2000, 87 (02) :149-158

[6] Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain [J].

Eisenach, JC ;

Rauck, RL ;

Curry, R .

PAIN, 2003, 105 (1-2) :65-70

[7] State-dependent opioid control of pain [J].

Fields, H .

NATURE REVIEWS NEUROSCIENCE, 2004, 5 (07) :565-575

[8] The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex [J].

Johansen, JP ;

Fields, HL ;

Manning, BH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :8077-8082

[9] Opioid self-administration in the nerve-injured rat [J].

Martin, Thomas J. ;

Kim, Susy A. ;

Buechler, Nancy L. ;

Porreca, Frank ;

Eisenach, James C. .

ANESTHESIOLOGY, 2007, 106 (02) :312-322

[10] Direct evidence for the involvement of endogenous β-endorphin in the suppression of the morphine-induced rewarding effect under a neuropathic pain-like state [J].

Niikura, Keiichi ;

Narita, Minoru ;

Narita, Michiko ;

Nakamura, Atsushi ;

Okutsu, Daiki ;

Ozeki, Ayumi ;

Kurahashi, Kana ;

Kobayashi, Yasuhisa ;

Suzuki, Masami ;

Suzuki, Tsutomu .

NEUROSCIENCE LETTERS, 2008, 435 (03) :257-262