Mosquitoes do senesce: Departure from the paradigm of constant mortality

被引:135
作者
Styer, Linda M.
Carey, James R.
Wang, Jane-Ling
Scott, Thomas W.
机构
[1] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Stat, Davis, CA 95616 USA
关键词
AEDES-AEGYPTI DIPTERA; PUERTO-RICO; CUTICULAR HYDROCARBONS; LIFE-SPAN; AGE; CULICIDAE; TRANSMISSION; SURVIVAL; MODEL; POPULATION;
D O I
10.4269/ajtmh.2007.76.111
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Although variation in mortality is considered by virtually all vector-borne disease specialists to be one of the most important determinants of an arthropod's capacity to transmit pathogens, the operational assumption often is that insect vector mortality is independent of age. Acceptance of the non-senescence assumption leads to the erroneous conclusion that mosquito age is unimportant, results in misleading predictions regarding disease reductions after vector control, and represses study of other aspects of mosquito biology that change with age. We brought large-scale laboratory life table techniques (N > 100,000) to bear on the question of age-dependent mortality in the mosquito vector of dengue virus, Aedes aegypti. Mortality was highly age dependent in both sexes. Mortality was low at young ages (< 10 days old), steadily increased at middle ages, and decelerated at older ages. A newly derived age-dependent model of pathogen transmission shows the importance of young mosquitoes and population age structure to transmission dynamics. Departure from the age-independent mortality paradigm encourages research on overlooked complexities in mosquito biology, the need for innovative methods to study mosquito population dynamics, and the need to study age-dependent changes for an accurate understanding of mosquito biology and pathogen transmission.
引用
收藏
页码:111 / 117
页数:7
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