Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon expressing antigen 85A

被引：52

作者：

Kirman, JR

Turon, T

Su, H

Li, A

Kraus, C

Polo, JM

Belisle, J

Morris, S

Seder, RA

机构：

[1] Vaccine Res Ctr, Cellular Immunol Sect, NIH, Bethesda, MD 20892 USA

[2] Natl Allergy & Infect Dis, Immunogenet Lab, NIH, Bethesda, MD USA

[3] Food & Drug Adm, Bethesda, MD USA

[4] Chiron Corp, Vaccines Res, Emeryville, CA USA

[5] Colorado State Univ, Dept Microbiol, Ft Collins, CO USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 01期

关键词：

D O I：

10.1128/IAI.71.1.575-579.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunogenicity of a plasmid DNA vaccine incorporating Sindbis virus RNA replicase functions (pSINCP) and expressing antigen 85A (Ag85A) from Mycobacterium tuberculosis was compared with a conventional plasmid DNA vector encoding Ag85A. pSINCP-85A was highly immunogenic in mice and gave enhanced long-term protection against M. tuberculosis compared with the conventional vector.

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页码：575 / 579

页数：5

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