Kinetics of Thiol/Disulfide Exchange Correlate Weakly with the Restoring Force in the Disulfide Moiety

被引：82

作者：

Kucharski, Timothy J. ^{[1
]}

Huang, Zhen ^{[1
]}

Yang, Qing-Zheng ^{[1
]}

Tian, Yancong ^{[1
]}

Rubin, Nicholas C. ^{[1
]}

Concepcion, Carlos D. ^{[1
]}

Boulatov, Roman ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 38期

基金：

美国国家科学基金会;

关键词：

kinetics; macrocycles; nucleophilic substitution; strained molecules; sulfur; INTERCHANGE; SUBSTITUTION; SPECTROSCOPY; SOLVATION; CHEMISTRY; MECHANISM; BOND;

D O I：

10.1002/anie.200901511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

S-S-Stretch! A series of increasingly strained macrocyclic disulfides investigated experimentally and by high-level DFT calculations reveals that the kinetics of thiol/disulfide exchange are independent of the restoring force in the disulfide moiety. This finding is consistent with the SN2 mechanism of thiol/disulfide exchange and lends insight into the acceleration of disulfide reduction upon stretching of certain proteins. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：7040 / 7043

页数：4

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