TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)

被引：229

作者：

Bodmer, JL

Burns, K

Schneider, P

Hofmann, K

Steiner, V

Thome, M

Bornand, T

Hahne, M

Schroter, M

Becker, K

Wilson, A

French, LE

Browning, JL

MacDonald, HR

Tschopp, J

机构：

[1] UNIV LAUSANNE,LUDWIG INST CANC RES,LAUSANNE BRANCH,LAUSANNE,SWITZERLAND

[2] SWISS INST EXPT CANC RES,BIL RES CTR,CH-1066 EPALINGES,SWITZERLAND

[3] UNIV GENEVA,SCH MED,DEPT DERMATOL,CH-1211 GENEVA 4,SWITZERLAND

[4] BIOGEN INC,DEPT IMMUNOL & INFLAMMAT,CAMBRIDGE,MA 02142

来源：

IMMUNITY | 1997年 / 6卷 / 01期

关键词：

D O I：

10.1016/S1074-7613(00)80244-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis. Overexpression of TRAMP leads to two major responses, NF-kappa B activation and apoptosis. TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.

引用

页码：79 / 88

页数：10

共 52 条

[1] CRYSTAL-STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX - IMPLICATIONS FOR TNF RECEPTOR ACTIVATION
BANNER, DW
DARCY, A
JANES, W
GENTZ, R
SCHOENFELD, HJ
BROGER, C
LOETSCHER, H
LESSLAUER, W
[J]. CELL, 1993, 73 (03) : 431 - 445
[2] A NOVEL PROTEIN THAT INTERACTS WITH THE DEATH DOMAIN OF FAS/APO1 CONTAINS A SEQUENCE MOTIF RELATED TO THE DEATH DOMAIN
BOLDIN, MP
VARFOLOMEEV, EE
PANCER, Z
METT, IL
CAMONIS, JH
WALLACH, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) : 7795 - 7798
[3] SELF-ASSOCIATION OF THE DEATH DOMAINS OF THE P55 TUMOR-NECROSIS-FACTOR (TNF) RECEPTOR AND FAS/APO1 PROMPTS SIGNALING FOR TNF AND FAS/APO1 EFFECTS
BOLDIN, MP
METT, IL
VARFOLOMEEV, EE
CHUMAKOV, I
SHEMERAVNI, Y
CAMONIS, JH
WALLACH, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) : 387 - 391
[4] Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
Boldin, MP
Goncharov, TM
Goltsev, YV
Wallach, D
[J]. CELL, 1996, 85 (06) : 803 - 815
[5] BORDIER C, 1981, J BIOL CHEM, V256, P1604
[6] THE PROTEIN BCL-2-ALPHA DOES NOT REQUIRE MEMBRANE ATTACHMENT, BUT 2 CONSERVED DOMAINS TO SUPPRESS APOPTOSIS
BORNER, C
MARTINOU, I
MATTMANN, C
IRMLER, M
SCHAERER, E
MARTINOU, JC
TSCHOPP, J
[J]. JOURNAL OF CELL BIOLOGY, 1994, 126 (04) : 1059 - 1068
[7] Preparation and characterization of soluble recombinant heterotrimeric complexes of human lymphotoxins alpha and beta
Browning, JL
Miatkowski, K
Griffiths, DA
Bourdon, PR
Hession, C
Ambrose, CM
Meier, W
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (15) : 8618 - 8626
[8] LYMPHOTOXIN-BETA, A NOVEL MEMBER OF THE TNF FAMILY THAT FORMS A HETEROMERIC COMPLEX WITH LYMPHOTOXIN ON THE CELL-SURFACE
BROWNING, JL
NGAMEK, A
LAWTON, P
DEMARINIS, J
TIZARD, R
CHOW, EPC
HESSION, C
OBRINEGRECO, B
FOLEY, SF
WARE, CF
[J]. CELL, 1993, 72 (06) : 847 - 856
[9] A flexible motif search technique based on generalized profiles
Bucher, P
Karplus, K
Moeri, N
Hofmann, K
[J]. COMPUTERS & CHEMISTRY, 1996, 20 (01): : 3 - 23
[10] BIOLOGICAL PROPERTIES OF A CD4 IMMUNOADHESIN
BYRN, RA
MORDENTI, J
LUCAS, C
SMITH, D
MARSTERS, SA
JOHNSON, JS
COSSUM, P
CHAMOW, SM
WURM, FM
GREGORY, T
GROOPMAN, JE
CAPON, DJ
[J]. NATURE, 1990, 344 (6267) : 667 - 670

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