Disturbance of automatic auditory change detection in dementia associated with Parkinson's disease: A mismatch negativity study

被引：51

作者：

Bronnick, Kolbjorn S. ^{[1
]}

Nordby, Helge ^{[3
]}

Larsen, Jan Petter ^{[1
,4
]}

Aarsland, Dag ^{[1
,2
,5
]}

机构：

[1] Stavanger Univ Hosp, Norwegian Ctr Movement Disorders, Helse Stavanger, Norway

[2] Stavanger Univ Hosp, Psychiat Clin, Helse Stavanger, Norway

[3] Univ Bergen, Dept Biol & Med Psychol, Fac Psychol, Bergen, Norway

[4] Stavanger Univ Hosp, Dept Neurol, Helse Stavanger, Norway

[5] Univ Bergen, Inst Clin Med, Bergen, Norway

来源：

NEUROBIOLOGY OF AGING | 2010年 / 31卷 / 01期

关键词：

Event-related potentials; Dementia; Parkinson's disease; Dementia with Lewy-bodies; Attention; Mismatch negativity; LEWY BODIES; ALZHEIMERS-DISEASE; SENSORY MEMORY; OCCIPITAL HYPOPERFUSION; SEROTONIN TRANSPORTERS; INFERIOR COLLICULUS; CLINICAL-DIAGNOSIS; DURATION; SPECT; SCALE;

D O I：

10.1016/j.neurobiolaging.2008.02.021

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: To investigate whether automatic auditory change detection, as measured by the mismatch negativity (MMN) event-related potential waveform, differs in dementia associated with Parkinson's disease (PDD) and dementia with Lewy-bodies (DLB) as compared to Alzheimer's disease (AD), Parkinson's disease without dementia (PD) and healthy control subjects (HC). Method: Seventeen DLB, 15 PDD, 16 PD, 16 AD patients and 18 HC subjects participated. A passive MMN event-related potential paradigm and an oddball-distractor reaction time paradigm were presented. Results: The PDD patients had reduced MMN area and amplitude compared to the DLB, PD, and the HC groups. The MMN area correlated significantly with number of missed target stimuli in the oddball-distractor task, and the PDD group missed targets significantly more often than the DLB group. Conclusion: The results indicate that PDD patients to a larger degree than patients with DLB have a deficit of automatic auditory change detection that contributes to impairment in their ability to selectively attend and respond to deviant auditory stimuli. (C) 2008 Elsevier Inc. All fights reserved.

引用

页码：104 / 113

页数：10

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