A competing risks analysis of bloodstream infection after stem-cell transplantation using subdistribution hazards and cause-specific hazards

被引：64

作者：

Beyersmann, Jan ^{[2
]}

Dettenkofer, Markus ^{[1
,3
]}

Bertz, Hartmut ^{[4
]}

Schumacher, Martin ^{[1
]}

机构：

[1] Univ Med Ctr Freiburg, Inst Med Biometry & Med Informat, D-79104 Freiburg, Germany

[2] Univ Freiburg, Freiburg Ctr Data Anal & Modelling, D-79104 Freiburg, Germany

[3] Univ Med Ctr Freiburg, Inst Environm Med & Hosp Epidemiol, D-79106 Freiburg, Germany

[4] Univ Med Ctr Freiburg, Dept Hematol & Oncol, D-79106 Freiburg, Germany

来源：

STATISTICS IN MEDICINE | 2007年 / 26卷 / 30期

关键词：

cumulative incidence function; Fine and Gray model; baseline hazard; hospital infection;

D O I：

10.1002/sim.3006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

After peripheral blood stem-cell transplantation, patients treated for severe haematologic diseases enter a critical phase (neutropenia). Analysis of bloodstream infection during neutropenia has to account for competing risks. Separate Cox analyses of all cause-specific hazards are the standard technique of choice, but are hard to interpret when the overall effects of covariates on the cumulative incidence function (CIF) are of interest. Proportional subdistribution hazards modelling of the subdistribution of the CIF is establishing itself as an interpretation-friendly alternative. We apply both methods and discuss their relative merits. Copyright 2007 John Wiley & Sons, Ltd.

引用

页码：5360 / 5369

页数：10

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