Phytoconstituents from Vitex agnus-castus fruits

被引：61

作者：

Chen, Shao-Nong ^{[1
]}

Friesen, J. Brent ^{[2
]}

Webster, Donna ^{[1
,3
]}

Nikolic, Dejan ^{[1
]}

van Breemen, Richard B. ^{[1
]}

Wang, Z. Jim ^{[3
]}

Fong, Harry H. S. ^{[1
]}

Farnsworth, Norman R. ^{[1
]}

Pauli, Guido F. ^{[1
]}

机构：

[1] Univ Illinois, UIC NIH Ctr Bot Dietary Supplements Res, PCRPS, Dept Med Chem & Pharmacognosy,Coll Pharm, Chicago, IL 60612 USA

[2] Dominican Univ, Rosary Coll Arts & Sci, River Forest, IL 60305 USA

[3] Univ Illinois, Dept Biopharmaceut Sci, Coll Pharm, Chicago, IL 60612 USA

来源：

FITOTERAPIA | 2011年 / 82卷 / 04期

关键词：

Vitex agnus-castus; Labdane diterpene; Viteagnusin I; Flavonoids; Opioid activity; EXTRACTS; DITERPENOIDS; RECEPTOR; CONSTITUENTS; PROLACTIN; FLAVONOLS;

D O I：

10.1016/j.fitote.2010.12.003

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：528 / 533

页数：6

共 34 条

[1]

Huazhongilexone is not 3′,5,5′,7-tetrahydroxyflavanone.: Preparation of 3′,5′-dimethoxy-5,7-dihydroxyflavanone [J].