Interactions between subunits of the Mediator complex with gene-specific transcription factors

被引：104

作者：

Borggrefe, Tilman ^{[1
]}

Yue, Xiaojing ^{[1
]}

机构：

[1] Max Planck Inst Immunobiol & Epigenet, Dept Cellular & Mol Immunol, D-79108 Freiburg, Germany

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2011年 / 22卷 / 07期

关键词：

Mediator complex; Transcriptional regulation; RNA polymerase; Coactivator; RNA-POLYMERASE-II; THYROID-HORMONE RECEPTOR; PROLIFERATOR-ACTIVATED RECEPTOR; CYCLIN-DEPENDENT KINASES; HUMAN CDK8 SUBCOMPLEX; COACTIVATOR COMPLEX; MAMMALIAN MEDIATOR; BINDING PROTEIN; NUCLEAR RECEPTORS; GLUCOCORTICOID-RECEPTOR;

D O I：

10.1016/j.semcdb.2011.07.022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Mediator complex forms the bridge between gene-specific transcription factors and the RNA polymerase II (RNAP II) machinery. Mediator is a large polypetide complex consisting of about thirty polypeptides that are mostly conserved from yeast to human. Mediator coordinates RNAP II recruitment, phosphorylation of the C-terminal domain of RNAP II, enhancer-loop formation and post-initiation events. The focus of the review is to summarize the current knowledge of transcription factor/Mediator interactions in higher eukaryotes and illuminate the physiological and gene-selective roles of Mediator. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：759 / 768

页数：10

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