Sex Differences in the Association between Serum Levels of Testosterone and Frailty in an Elderly Population: The Toledo Study for Healthy Aging

被引:70
作者
Carcaillon, Laure [1 ]
Blanco, Carmen [2 ]
Alonso-Bouzon, Cristina [3 ]
Alfaro-Acha, Ana [4 ]
Garcia-Garcia, Francisco-Jose [4 ]
Rodriguez-Manas, Leocadio [1 ,3 ]
机构
[1] Hosp Univ Getafe, Fdn Invest Biomed, Madrid, Spain
[2] Hosp Univ Getafe, Serv Anal Clin, Madrid, Spain
[3] Hosp Univ Getafe, Serv Geriatria, Madrid, Spain
[4] Complejo Hosp Toledo, Hosp Virgen Valle, Serv Geriatria, Toledo, Spain
来源
PLOS ONE | 2012年 / 7卷 / 03期
关键词
MUSCLE STRENGTH; BODY-COMPOSITION; TRANSDERMAL TESTOSTERONE; PHYSICAL PERFORMANCE; WOMENS HEALTH; OLDER-ADULTS; MEN; BONE; EXTREMITY; VALIDITY;
D O I
10.1371/journal.pone.0032401
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Age-associated decline in testosterone levels represent one of the potential mechanisms involved in the development of frailty. Although this association has been widely reported in older men, very few data are available in women. We studied the association between testosterone and frailty in women and assessed sex differences in this relationship. Methods: We used cross-sectional data from the Toledo Study for Healthy Aging, a population-based cohort study of Spanish elderly. Frailty was defined according to Fried's approach. Multivariate odds-ratios (OR) and 95% confidence intervals (CI) associated with total (TT) and free testosterone (FT) levels were estimated using polytomous logistic regression. Results: In women, there was a U-shaped relationship between FT levels and frailty (p for FT2 = 0.03). In addition, very low levels of FT were observed in women with >= 4 frailty criteria (age-adjusted geometric means = 0.13 versus 0.37 in subjects with <4 components, p = 0.010). The association of FT with frailty appeared confined to obese women (p-value for interaction = 0.05). In men, the risk of frailty levels linearly decreased with testosterone (adjusted OR for frailty = 2.9 (95%CI, 1.6-5.1) and 1.6 (95%CI, 1.0-2.5), for 1 SD decrease in TT and FT, respectively). TT and FT showed association with most of frailty criteria. No interaction was found with BMI. Conclusion: There is a relationship between circulating levels of FT and frailty in older women. This relation seems to be modulated by BMI. The relevance and the nature of the association of FT levels and frailty are sex-specific, suggesting that different biological mechanisms may be involved.
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页数:9
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