Increased cerebral oxidative damage and decreased antioxidant defenses in ovariectomized and sham-operated rats supplemented with vitamin A

被引：22

作者：

Behr, Guilherme Antonio ^{[1
,2
,3
,4
]}

Schnorr, Carlos Eduardo ^{[1
]}

Simoes-Pires, Andre ^{[1
]}

da Motta, Leonardo Lisboa ^{[1
]}

Frey, Benicio N. ^{[3
,4
]}

Fonseca Moreira, Jose Claudio ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Ctr Oxidat Stress Res, Prof Tuiskon Dick Dept Biochem, Inst Hlth Basic Sci, BR-90035003 Porto Alegre, RS, Brazil

[2] Minist Educ Brazil, Capes Fdn, BR-70040020 Brasilia, DF, Brazil

[3] McMaster Univ, Womens Hlth Concerns Clin, Hamilton, ON L8P 3B6, Canada

[4] McMaster Univ, Mood Disorders Program, Dept Psychiat & Behav Neurosci, Hamilton, ON L8P 3B6, Canada

来源：

CELL BIOLOGY AND TOXICOLOGY | 2012年 / 28卷 / 05期

关键词：

Behavior; Central nervous system; Menopause; Ovariectomy; Redox profile; Vitamin A; ANXIETY-LIKE BEHAVIOR; COMPLEMENTARY THERAPIES; INCREASED; 3-NITROTYROSINE; BIOENERGETICS STATES; EXPLORATORY ACTIVITY; SUBSTANTIA-NIGRA; RETINOIC ACID; ANIMAL-MODEL; HOT FLASHES; STRESS;

D O I：

10.1007/s10565-012-9226-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Previous studies have linked oxidative stress with aging and aging-related processes, including menopause. Abnormalities in the redox state similar to those observed in menopausal women can be modeled experimentally with rat ovariectomy. The aim of the present study was to investigate the effects of vitamin A (retinol palmitate) supplementation (500 or 1,500 IU kg(-1) day(-1) for 30 days) on behavioral parameters and brain redox profile in ovariectomized (OVX) and sham-operated rats. Ovariectomy caused pronounced uterine atrophy and decreased locomotor/exploratory activity. Moreover, we found increased hypothalamic and frontal cortex superoxide dismutase/catalase (SOD/CAT) ratio and decreased hippocampal thiol content, accompanied by increased frontal cortex lipid oxidative damage (TBARS) in OVX rats. Vitamin A at 1,500 IUkg(-1) day(-1) decreased exploratory behavior and decreased total hippocampal thiol content in sham-operated rats, increased hippocampal SOD/CAT ratio and decreased total antioxidant potential in the hippocampus of both sham and OVX groups, and increased cortical TBARS levels in OVX rats. Thus, vitamin A may induce a pro-oxidant state in discrete brain regions of sham-operated and OVX rats. These results suggest some caution regarding the use of high doses of vitamin A supplementation during menopause.

引用

页码：317 / 330

页数：14

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