Regulation of cyclic nucleotide-gated channels

被引：111

作者：

Bradley, J

Reisert, J

Frings, S

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[2] Univ Heidelberg, Abt Mol Physiol, D-69120 Heidelberg, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.conb.2005.05.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cyclic nucleoticle-gated (CNG) channels are found in several cell types, and are best studied in photoreceptors and olfactory sensory neurons. There, CNG channels are gated by the second messengers of the visual and olfactory signalling cascades, cGMP and cAMP respectively, and operate as transduction channels generating the stimulus-induced receptor potentials. In visual and olfactory sensory cells CNG channels conduct cationic currents. Calcium can contribute a large fraction of this current, and calcium influx serves a modulatory role in CNG-channel mediated signal transduction. There have been recent developments in our understanding of how the regulation of CNG channels contributes to the physiological properties of photoreceptors and olfactory sensory cells, and in particular on the role of calcium-mediated feedback.

引用

页码：343 / 349

页数：7

共 47 条

[1] Cyclic GMP-gated channels of bovine rod photoreceptors: Affinity, density and stoichiometry of Ca2+-calmodulin binding sites [J].