Synthesis of (R)-(+)-methyl 3-amino-3-(5-hydroxy-2-pyridinyl)propanoate an analog of L-azatyrosine

被引:9
作者
Adamczyk, M [1 ]
Reddy, RE [1 ]
机构
[1] Abbott Labs, Dept Chem, Div Diagnost, Abbott Pk, IL 60064 USA
关键词
D O I
10.1016/S0957-4166(01)00186-0
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A concise asymmetric synthesis of (R)-(+)-methyl 3-amino-3-(5-hydroxy-2-pyridinyl)propanoate 2. a beta -amino acid analog of L-azatyrosine 1 starting from the commercially available (-)-Andersen reagent (-)-3 in good overall yield is described. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1047 / 1054
页数:8
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