A model of slow plateau-like oscillations based upon the fast Na+ current in a window mode

被引：26

作者：

Cymbalyuk, GS ^{[1
]}

Calabrese, RL ^{[1
]}

机构：

[1] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

来源：

NEUROCOMPUTING | 2001年 / 38卷

基金：

美国国家卫生研究院;

关键词：

slow plateau-like oscillations; window current; sodium plateau;

D O I：

10.1016/S0925-2312(01)00414-3

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

Divalent ions, which block Ca2+ currents, combined with partial block of outward currents give rise to slow plateau-like oscillations (10-50 s period) with long duration plateaus and long inter-plateau intervals in leech heart interneurons (Opdyke, Calabrese, J. Comp. Physiol. 175 (1994) 781-789.) We present a simplified mathematical model that replicates the main characteristics of these observations and suggests an underlying biophysical mechanism. A model containing transient Na+ current (I-Na), leakage and outward currents can generate oscillations with long plateau duration. The plateaus arise from a window mode of I-Na and do not require noninactivating Na+ current (I-Na). The long inter-plateau intervals are produced reliably after including I-p. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：159 / 166

页数：8

共 16 条

[1] SYNCHRONIZED OSCILLATORY ACTIVITY IN LEECH NEURONS INDUCED BY CALCIUM-CHANNEL BLOCKERS [J].