Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: An fMRI study

被引：178

作者：

Bryant, Richard A. ^{[1
,2
]}

Kemp, Andrew H. ^{[2
,3
]}

Felmingham, Kim L. ^{[2
,3
]}

Liddell, Belinda ^{[2
,3
]}

Olivieri, Gloria ^{[2
,4
]}

Peduto, Anthony ^{[2
,4
]}

Gordon, Evian ^{[2
,5
,6
]}

Williams, Leanne M. ^{[2
,3
]}

机构：

[1] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia

[2] Westmead Hosp, Brain Dynam Ctr, Sydney, NSW, Australia

[3] Univ Sydney, Dept Psychol, Sydney, NSW 2006, Australia

[4] Westmead Hosp, MRI Unit, Dept Radiol, Sydney, NSW, Australia

[5] Univ Sydney, Div Psychol Med, Sydney, NSW 2006, Australia

[6] Brain Resource Co, Brain Resource Int Database, Sydney, NSW, Australia

来源：

HUMAN BRAIN MAPPING | 2008年 / 29卷 / 05期

关键词：

fMRI; medial prefrontal cortex; amygdala; posttraumatic stress disorder; fear;

D O I：

10.1002/hbm.20415

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Biological models of posttraumatic stress disorder (PTSD) suggest that patients will display heightened amygdala but decreased medial prefrontal activity during processing of fear stimuli. However, a rapid and automatic alerting mechanism for responding to nonconscious signals of fear suggests that PTSD may display heightened rather than decreased MPFC under nonconscious processing of fear stimuli. This study used functional magnetic resonance imaging to examine blood oxygenation level-dependent signal changes during nonconscious presentation (16.7 ms, masked) of fearful and neutral faces in 15 participants with PTSD and 15 age and sex-matched healthy control participants. Results indicate that PTSD participants display increased amygdala and MPFC activity during nonconscious processing of fearful faces. These data extend existing models by suggesting that the impaired MPFC activation in PTSD may be limited to conscious fear processing.

引用

页码：517 / 523

页数：7

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