Serological responses to Cryptosporidium antigens among users of surface- vs. ground-water sources

被引:13
作者
Frost, FJ
Kunde, TR
Muller, TB
Craun, GF
Katz, LM
Hibbard, AJ
Calderon, RL
机构
[1] Lovelace Clin Fdn, Albuquerque, NM 87108 USA
[2] Gunther F Craun & Associates, Staunton, VA 24401 USA
[3] US EPA, Natl Hlth & Environm Effects Lab, Res Triangle Pk, NC 27711 USA
[4] Mississippi Valley Reg Blood Ctr, Davenport, IA USA
[5] Amer Red Cross, Madison, WI 53705 USA
关键词
D O I
10.1017/S0950268803001341
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Cryptosporidium oocysts are commonly detected in surface-derived drinking water. However, the public health significance of these findings is unclear. This study compared serological responses to two Cryptosporidium antigen groups for blood donors and college students using chlorinated and filtered river water vs. ground-water sources. The surface water received agricultural and domestic sewage discharges upstream. Participants from the surface-water city had a higher relative prevalence (RP) of a serological response to the 15/17-kDa antigen group (72.3 vs. 52.4%, RP = 1.36, P < 0.001) and to the 27-kDa antigen group (82.6 vs. 72.5%, RP = 1.14, P < 0.02). Multivariate logistic regression analysis found that the people with a shorter duration of residence or drinking bottled water also had a lower seropositivity for each marker. Use of private wells was associated with a higher prevalence of response to the 15/17-kDa markers. Seroconversion to the 15/17-kDa antigen group was more common in the residents of the city using surface water. These findings are consistent with an increased risk of Cryptosporidium infection for users of surface-derived drinking water compared with users of municipal ground-water-derived drinking water. Users of private well water may also have an increased risk of infection.
引用
收藏
页码:1131 / 1138
页数:8
相关论文
共 23 条
[1]  
Craun GF, 1998, J AM WATER WORKS ASS, V90, P81
[2]  
DAWSON A, P 1994 WORKSH CRYPT
[3]  
EGOROV A, IN PRESS ANN EPIDEMI
[4]  
Friedman ND, 2001, VENEREOLOGY, V14, P21
[5]  
Frost F, 1997, J AM WATER WORKS ASS, V89, P8
[6]  
Frost FJ, 1998, INFECT IMMUN, V66, P4008
[7]  
Frost FJ, 2003, DRINKING WATER AND INFECTIOUS DISEASE: ESTABLISHING THE LINKS, P165
[8]   Comparisons of ELISA and Western blot assays for detection of Cryptosporidium antibody [J].
Frost, FJ ;
de la Cruz, AA ;
Moss, DM ;
Curry, M ;
Calderon, RL .
EPIDEMIOLOGY AND INFECTION, 1998, 121 (01) :205-211
[9]   A two-year follow-up survey of antibody to Cryptosporidium in Jackson County, Oregon following an outbreak of waterborne disease [J].
Frost, FJ ;
Calderon, RL ;
Muller, TB ;
Curry, M ;
Rodman, JS ;
Moss, DM ;
de la Cruz, AA .
EPIDEMIOLOGY AND INFECTION, 1998, 121 (01) :213-217
[10]   Paired city Cryptosporidium serosurvey in the southwest USA [J].
Frost, FJ ;
Muller, T ;
Craun, GF ;
Calderon, RL ;
Roefer, PA .
EPIDEMIOLOGY AND INFECTION, 2001, 126 (02) :301-307