The dual adverse effects of TGF-β secretion on tumor progression

被引：76

作者：

Trapani, JA ^{[1
]}

机构：

[1] Peter MacCallum Canc Inst, Canc Immunol Program, Melbourne, Vic 3002, Australia

来源：

CANCER CELL | 2005年 / 8卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2005.10.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

When a cancer escapes the growth-inhibitory effects of TGF-beta secreted by cancer cells themselves or by cells in the local stroma, a further adverse outcome for the host is the associated TGF-beta-induced suppression of anticancer T cell immunity. In addition to the previously described dampening of T cell activation and proliferation, TGF-beta markedly and directly suppresses the transcription of genes encoding multiple key proteins of the "cytotoxic program" of CD8(+) CTL, such as perforin and granzymes, cytotoxins that act through the granule exocytosis pathway. The findings described below suggest that TGF-beta and its signaling pathways will be major targets for novel cancer therapeutics.

引用

页码：349 / 350

页数：2

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