Thyroid hormone receptor β1 is expressed in the human hair follicle

被引：83

作者：

Billoni, N ^{[1
]}

Buan, B ^{[1
]}

Gautier, B ^{[1
]}

Gaillard, O ^{[1
]}

Mahé, YF ^{[1
]}

Bernard, BA ^{[1
]}

机构：

[1] LOreal Hair Biol Grp, LOreal Adv Res Labs, Life Sci, F-92583 Clichy, France

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2000年 / 142卷 / 04期

关键词：

human hair follicle; thyroid hormone receptor; triiodothyronine;

D O I：

10.1046/j.1365-2133.2000.03408.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

To understand better the mechanisms by which thyroid hormone can exert its effects on the hair follicle, we looked for the expression of members of the thyroid hormone receptor (TR) family in human hair follicles. Immunoreactive TRs were detected in both dermal and epithelial compartments of the human pilosebaceous unit. Using reverse transcriptase-polymerase chain reaction, we established that TR beta 1 was the predominant form of TR expressed in the human hair follicle. In addition, we investigated the effects of 3,3',5-triiodo-L-thyronine (T3) on the survival of human hair follicles in vitro, to understand the role of this thyroid hormone on hair follicle homeostasis. A physiological level of free T3 significantly enhanced human hair survival in vitro.

引用

页码：645 / 652

页数：8

共 31 条

[1]

Ahsan Mohammad Kamrul, 1998, Journal of Medical Investigation, V44, P179

[2]

Molecular and structural biology of thyroid hormone receptors [J].

Apriletti, JW ;

Ribeiro, RCJ ;

Wagner, RL ;

Feng, W ;

Webb, P ;

Kushner, PJ ;

West, BL ;

Nilsson, S ;

Scanlan, TS ;

Fletterick, RJ ;

Baxter, JD .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1998, 25 :S2-S11

[3]

The expression pattern of thyroid hormone response genes in the tadpole tail identifies multiple resorption programs [J].

Berry, DL ;

Schwartzman, RA ;

Brown, DD .

DEVELOPMENTAL BIOLOGY, 1998, 203 (01) :12-23

[4]

Billoni N, 1997, ACTA DERM-VENEREOL, V77, P350

[5]

Boyera N., 1998, International Journal of Cosmetic Science, V20, P151, DOI 10.1046/j.1467-2494.1998.171747.x

[6]

STRUCTURE AND EXPRESSION OF THE HAIRLESS GENE OF MICE [J].

CACHONGONZALEZ, MB ;

FENNER, S ;

COFFIN, JM ;

MORAN, C ;

STOYE, JP ;

BEST, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7717-7721

[7]

DIFFUSE THINNING OF HAIR IN IODIDE-INDUCED HYPOTHYROIDISM [J].

CHAPMAN, RS ;

MAIN, RA .

BRITISH JOURNAL OF DERMATOLOGY, 1967, 79 (02) :103-&

[8]

Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia [J].

Cichon, S ;

Anker, M ;

Vogt, IR ;

Rohleder, H ;

Pützstück, M ;

Hillmer, A ;

Farooq, SA ;

Al-Dhafri, KS ;

Ahmad, M ;

Haque, S ;

Rietschel, M ;

Propping, P ;

Kruse, R ;

Nöthen, MM .

HUMAN MOLECULAR GENETICS, 1998, 7 (11) :1671-1679

[9]

Immunohistochemical analysis of tissue remodelling during the anagen-catagen transition of the human hair follicle [J].

Commo, S ;

Bernard, BA .

BRITISH JOURNAL OF DERMATOLOGY, 1997, 137 (01) :31-38

[10]

DIEUSAEWRT P, 1996, ANAL MED, P1019

← 1 2 3 4 →